Chemistry & Drug Discovery Search API
Query ChEMBL bioactivity (IC50/Ki/Kd/EC50), PubChem structures and properties, and Open Targets target-disease associations from one endpoint. Pre-shaped JSON for AI-driven drug discovery, cheminformatics, and biomedical research.
What is Chemistry Search API?
Semantic search across ChEMBL, PubChem, and Open Targets. Returns ranked records with source URLs ready for downstream LLMs.
- Endpoint
- POST /api/search/chemistry
- Authentication
- API key · x-api-key header
- Cost
- 30 credits / call
- Rate limit
- 60 req / min
- Response
- Structured JSON
Try Chemistry Search Live
Enter your API key and run a real query against the live endpoint.
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Integration guide
Copy a snippet, replace your API key, run. Works in any HTTP client — examples below in cURL, JavaScript, and Python.
/api/search/chemistryhttps://www.apipick.comSemantic search across ChEMBL, PubChem, and Open Targets. Returns ranked records with source URLs ready for downstream LLMs.
querystringrequiredNatural-language search query
max_num_resultsintegeroptional1–5, default 5
relevance_thresholdnumberoptional0.0–1.0 quality filter
country_codestringoptionalISO country code (e.g. US, GB)
start_datestringoptionalISO date YYYY-MM-DD
end_datestringoptionalISO date YYYY-MM-DD
curl -X POST "https://www.apipick.com/api/search/chemistry" \
-H "Content-Type: application/json" \
-H "x-api-key: YOUR_API_KEY" \
-d '{
"query": "Kinase inhibitor selectivity for EGFR",
"max_num_results": 5,
"country_code": "US",
"start_date": "2026-01-01"
}'{
"query": "Kinase inhibitor selectivity for EGFR",
"results": [
{
"title": "Example result",
"url": "https://example.com/article",
"snippet": "Short excerpt of the page content…",
"source_type": "web",
"published_at": "2026-04-15",
"score": 0.92
}
],
"result_count": 1,
"credits_used": 30,
"remaining_credits": 99
}Rate limits
Throttling is per API key, sliding 60-second window. Hit the limit and you get a clean 429 with a Retry-After header.
60req/min
Per API key, per endpoint. Sliding 60-second window.
3concurrent
Max simultaneous in-flight requests per API key.
X-RateLimit-LimitMaximum requests allowed per minuteX-RateLimit-RemainingRequests remaining in the current windowX-RateLimit-ResetSeconds until the current window resetsRetry-AfterSeconds to wait before retrying (only on 429)HTTP/1.1 429 Too Many Requests
Retry-After: 12
X-RateLimit-Limit: 60
X-RateLimit-Remaining: 0
X-RateLimit-Reset: 12
{
"error": "rate_limit_exceeded",
"message": "Rate limit exceeded: 60 requests/minute per API key. Retry after 12s.",
"retry_after": 12
}Frequently Asked Questions
Why is this 30 credits per call?
ChEMBL, PubChem, and Open Targets are large, structured scientific datasets that require ongoing index maintenance, so the endpoint is priced at 30 credits (≈ $0.03 per call) — a fraction of dedicated cheminformatics platforms.
Which sources are covered?
ChEMBL (bioactivity: IC50/Ki/Kd/EC50), PubChem (100M+ chemical structures and properties), and Open Targets (target-disease associations and validation). All three are queried in parallel.
Can I search by compound or target?
Yes. Pass a compound name, a target/gene, or a natural-language query like 'EGFR kinase inhibitor selectivity' and the endpoint ranks the most relevant records.
Date filtering?
Yes. Pass start_date and end_date in YYYY-MM-DD to scope to a specific window.
Tool schema for OpenAI / Claude?
GET /api/search/chemistry/tool-schema returns ready-to-paste OpenAI function and Claude tool-use definitions.
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