Sequences & Structures Search API
Query NCBI Nucleotide, Protein, Genome, Assembly, Protein Clusters, Conserved Domains, and Structure from a single endpoint. Pre-shaped JSON with accessions, organisms, lengths, and source databases for AI-driven bioinformatics.
What is Genomics Sequences Search API?
Semantic search across NCBI Nucleotide, Protein, Genome, Assembly, Protein Clusters, CDD, and Structure. Returns ranked records with source URLs ready for downstream LLMs.
- Endpoint
- POST /api/search/genomics-sequences
- Authentication
- API key · x-api-key header
- Cost
- 30 credits / call
- Rate limit
- 60 req / min
- Response
- Structured JSON
Try Sequences & Structures Search Live
Enter your API key and run a real query against the live endpoint.
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Integration guide
Copy a snippet, replace your API key, run. Works in any HTTP client — examples below in cURL, JavaScript, and Python.
/api/search/genomics-sequenceshttps://www.apipick.comSemantic search across NCBI Nucleotide, Protein, Genome, Assembly, Protein Clusters, CDD, and Structure. Returns ranked records with source URLs ready for downstream LLMs.
querystringrequiredNatural-language search query
max_num_resultsintegeroptional1–5, default 5
relevance_thresholdnumberoptional0.0–1.0 quality filter
curl -X POST "https://www.apipick.com/api/search/genomics-sequences" \
-H "Content-Type: application/json" \
-H "x-api-key: YOUR_API_KEY" \
-d '{
"query": "Human insulin protein sequence",
"max_num_results": 5
}'{
"query": "Human insulin protein sequence",
"results": [
{
"title": "Example result",
"url": "https://example.com/article",
"snippet": "Short excerpt of the page content…",
"source_type": "web",
"published_at": "2026-04-15",
"score": 0.92
}
],
"result_count": 1,
"credits_used": 30,
"remaining_credits": 99
}Rate limits
Throttling is per API key, sliding 60-second window. Hit the limit and you get a clean 429 with a Retry-After header.
60req/min
Per API key, per endpoint. Sliding 60-second window.
3concurrent
Max simultaneous in-flight requests per API key.
X-RateLimit-LimitMaximum requests allowed per minuteX-RateLimit-RemainingRequests remaining in the current windowX-RateLimit-ResetSeconds until the current window resetsRetry-AfterSeconds to wait before retrying (only on 429)HTTP/1.1 429 Too Many Requests
Retry-After: 12
X-RateLimit-Limit: 60
X-RateLimit-Remaining: 0
X-RateLimit-Reset: 12
{
"error": "rate_limit_exceeded",
"message": "Rate limit exceeded: 60 requests/minute per API key. Retry after 12s.",
"retry_after": 12
}Frequently Asked Questions
Why is this 30 credits per call?
The NCBI sequence, assembly, and structure databases are large scientific resources requiring ongoing index maintenance, so the endpoint is priced at 30 credits (≈ $0.03 per call) — a fraction of dedicated bioinformatics platforms.
Which sources are covered?
NCBI Nucleotide, Protein, Genome, Assembly, Protein Clusters, Conserved Domains (CDD), and Structure. All are queried in parallel and ranked together.
Can I search by accession or name?
Yes. Pass an accession, an organism, a molecule name, or a natural-language query like 'human insulin protein sequence' and the endpoint ranks the most relevant records.
What fields come back?
Records include titles, accessions, organism, sequence length, molecule type, and source database, plus a link to the NCBI record. Structured fields are preserved for downstream parsing.
Tool schema for OpenAI / Claude?
GET /api/search/genomics-sequences/tool-schema returns ready-to-paste OpenAI function and Claude tool-use definitions.
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