Genes & Variants Search API
Query NCBI Gene, dbSNP, ClinVar, dbVar, MedGen, and GTR from a single endpoint. Pre-shaped JSON with gene records, variant IDs, clinical significance, and genetic tests for AI-driven genomics and variant-interpretation workflows.
What is Genomics Genes & Variants Search API?
Semantic search across NCBI Gene, dbSNP, ClinVar, dbVar, MedGen, and GTR. Returns ranked records with source URLs ready for downstream LLMs.
- Endpoint
- POST /api/search/genomics-genes
- Authentication
- API key · x-api-key header
- Cost
- 30 credits / call
- Rate limit
- 60 req / min
- Response
- Structured JSON
Try Genes & Variants Search Live
Enter your API key and run a real query against the live endpoint.
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Integration guide
Copy a snippet, replace your API key, run. Works in any HTTP client — examples below in cURL, JavaScript, and Python.
/api/search/genomics-geneshttps://www.apipick.comSemantic search across NCBI Gene, dbSNP, ClinVar, dbVar, MedGen, and GTR. Returns ranked records with source URLs ready for downstream LLMs.
querystringrequiredNatural-language search query
max_num_resultsintegeroptional1–5, default 5
relevance_thresholdnumberoptional0.0–1.0 quality filter
curl -X POST "https://www.apipick.com/api/search/genomics-genes" \
-H "Content-Type: application/json" \
-H "x-api-key: YOUR_API_KEY" \
-d '{
"query": "BRCA1 gene function and cancer risk",
"max_num_results": 5
}'{
"query": "BRCA1 gene function and cancer risk",
"results": [
{
"title": "Example result",
"url": "https://example.com/article",
"snippet": "Short excerpt of the page content…",
"source_type": "web",
"published_at": "2026-04-15",
"score": 0.92
}
],
"result_count": 1,
"credits_used": 30,
"remaining_credits": 99
}Rate limits
Throttling is per API key, sliding 60-second window. Hit the limit and you get a clean 429 with a Retry-After header.
60req/min
Per API key, per endpoint. Sliding 60-second window.
3concurrent
Max simultaneous in-flight requests per API key.
X-RateLimit-LimitMaximum requests allowed per minuteX-RateLimit-RemainingRequests remaining in the current windowX-RateLimit-ResetSeconds until the current window resetsRetry-AfterSeconds to wait before retrying (only on 429)HTTP/1.1 429 Too Many Requests
Retry-After: 12
X-RateLimit-Limit: 60
X-RateLimit-Remaining: 0
X-RateLimit-Reset: 12
{
"error": "rate_limit_exceeded",
"message": "Rate limit exceeded: 60 requests/minute per API key. Retry after 12s.",
"retry_after": 12
}Frequently Asked Questions
Why is this 30 credits per call?
NCBI Gene, dbSNP, ClinVar and related datasets are large, continuously updated genomic resources that require ongoing index maintenance, so the endpoint is priced at 30 credits (≈ $0.03 per call) — a fraction of dedicated bioinformatics platforms.
Which sources are covered?
NCBI Gene (gene records), dbSNP (sequence variants), ClinVar (clinical significance of variants), dbVar (structural variants), MedGen (medical genetics), and GTR (Genetic Testing Registry). All are queried in parallel and ranked together.
Can I search by gene, rsID, or condition?
Yes. Pass a gene symbol (BRCA1), an rsID (rs334), a condition, or a natural-language query like 'pathogenic variants in CFTR' and the endpoint ranks the most relevant records.
Is this medical advice?
No. Results are informational retrieval from public genomic datasets only and must not be used for diagnosis or treatment decisions.
Tool schema for OpenAI / Claude?
GET /api/search/genomics-genes/tool-schema returns ready-to-paste OpenAI function and Claude tool-use definitions.
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